Rusholme is located about two miles south of Manchester city centre. Rusholme is bounded by Chorlton-on-Medlock to the north, Victoria Park and Longsight to the east, Fallowfield to the south and Moss Side to the west.
Wilmslow Road is part of the B5117, a thoroughfare running from Parrs Wood north into the city centre, traversing the campuses of the University of Manchester and Manchester Metropolitan University. It forms part of what is the busiest bus route in Europe, with many stops being serviced by a bus from one of many different bus companies every 60 to 90 seconds during peak times. A section of this road known locally as the Curry Mile contains at least 70 restaurants, takeaways and kebab houses specialising in the cuisines of South Asia and the Middle East. Appleby Lodge is a 1930s block of flats opposite Platt Fields Park.
The property occupies a prominent corner position on the junction of Wilmslow Road and Moss Lane East in a mixed use area.